I am an Associate Professor and Canada Research Chair (Tier 2) of Aquatic and Mechanistic Toxicology, in the Department of Biological Sciences at the University of Lethbridge.



My lab focuses on understanding effects of anthropogenic chemicals on aquatic organisms.  The majority of research in my lab is aimed at characterizing mechanisms of toxicity using molecular (genomic and epigenetic) and biochemical approaches.

We primarily use zebrafish (Danio rerio), fathead minnows (Pimephales promelas), and Japanese medaka (Oryzias latipes) as our model species .



Interested in graduate studies or postdoctoral positions?  Contact me to discuss current opportunities.

Graduate Student Opportunities: 

Postdoctoral opportunity in ecotoxicology (July 2021)

A postdoctoral position is available to investigate effects of contaminants on physiological performance of fishes, with an emphasis on reproductive performance. Contaminants of interest include UV stabilizers, brominated flame retardants, and PAHs. The primary goal is to use molecular and biochemical approaches to understand mechanisms of toxicity. Applicants should have a background in toxicology or fish physiology, and a strong background in molecular biology. Preference will be given to applicants that have experience in transcriptomics (cDNA microarrays or RNAseq), epigenomics (DNA methylation, ncRNAs), proteomics, or metabolomics .  

The ideal candidate is a motivated and creative researcher with an ability to develop and pursue their own ideas within the context of molecular and biochemical mechanisms of toxicity. The candidate should also have an interest in playing an active role in the mentorship of undergraduate and graduate students. Strong written and oral communication skills are essential. 

The University of Lethbridge provides a dynamic research environment. The lab is located in the Alberta Water and Environmental Sciences Building, which is home to the state-of-the-art Aquatic Research Facility that houses breeding cultures of fathead minnow, zebrafish, and Japanese medaka, and can also house lager fish species such as rainbow trout. The University is also home to the Southern Alberta Genome Science Centre and the Canadian Center for Behavioral Neuroscience. As such, there are opportunities for collaborative research and training opportunities within the institution. 

The University of Lethbridge is located in Lethbridge, which is the largest city in southern Alberta, Canada, with a population of approximately 100,000. It is situated within driving distance of the Rocky Mountains, Waterton Lakes National Park, Banff National Park, the cities of Calgary and Edmonton, and ski resorts including Castle Mountain, Lake Louise, Kananaskis, Fernie, and Whitefish, Montana, USA.

Funding for salary and benefits is secured for 2 years. The start date is flexible. Interested individuals should send a complete academic CV to

Information regarding postdoctoral studies at the University of Lethbridge is available at:






MSc Candidate


MSc Candidate


MSc Candidate


MSc Candidate


MSc Candidate


BSc Honours Student


BSc Honours Student




P. Razmara, J.J. Imbery, E. Koide, C.C Helbing, S.B. Wiseman, P.T. Gauthier, D.F. Bray, M. Needham, T. Haight, A. Zovoilis, G.G. Pyle. 2021. Mechanism of copper nanoparticle toxicity in rainbow trout olfactory mucosa. Environ. Pollut. 284, 117141.

K. Fujita, Z. Xia, G. Tomy, T. Montina, S. Wiseman. 2021. 1H NMR based metabolomic profiling of early life stage zebrafish (Danio rerio) exposed to weathered sediment-bound diluted bitumen Aquat. Toxicol. 232, 105766. 

S. Everitt, K. Fujita, S. MacPherson, M. Brinkmann, G. Pyle, S. Wiseman. 2021. Toxicity of Weathered Sediment-Bound Dilbit to Early Life-Stages of Zebrafish (Danio rerio). Environ. Sci. Technol. 55(3), 1721-1729. 


D. Van Essen, C. Devoy, J. Miller, P.D. Jones, S. Wiseman. 2020. Effects of the brominated flame retardant, TBCO, on development of zebrafish (Danio rerio) embryos. Chemosphere. 266, 129195.

J. Brunet, B.A. Graham, J. Klemish, T.M. Burg, D. Johnson, S. Wiseman. 2020. Batrachochytrium dendrobatidis from amphibian and eDNA. Herpetological Review. 51(4).

H. Meyer-Alert, S. Wiseman, S. Tang, M. Hecker, H. Hollert. 2020. Identification of molecular toxicity pathways across early life-stages of zebrafish exposed to PCB126 using a whole transcriptomics approach. Ecotox. Environ. Saf. 208, 111716.

H.A. Alharbi, S.B. Wiseman, J.P. Giesy. 2020. Effects of oil sands process affected water on solubility of polycyclic aromatic hydrocarbons. Environ. Sci. Technol. Water. 

J. Miller, A. Jamwal, Y. Ilnytskyy, A. Hontela, S. Wiseman. 2020. Exposure to dicamba elevates concentrations of S-adenosyl methionine but does not induce oxidative stress or alter DNA methylation in rainbow trout (Oncorhynchus mykiss) hepatocytes. Comp. Biochem. Physiol. D. Genom. Proteom. 36, 10744.

S. Everitt, S. MacPherson, M. Brinkmann, S. Wiseman, G.G Pyle. 2020. Effects of weathered sediment-bound dilbit on freshwater amphipods (Hyalella azteca). Submitted to Aquat. Toxicol. 228: 105630

M. Brinkmann, H. Alharbi, U. Fuchylo, S. Wiseman, G. Morandi, H. Peng, J. Giesy, P. Jones, M. Hecker. 2020. Mechanisms of pH-dependent uptake of ionizable organic chemicals by fish from oil sands process-affected water (OSPW). Environ. Sci. Technol. 54 (15): 9547–9555

J.A. Doering, J. Dubiel, S. Wiseman. 2020. Predicting early life stage mortality in birds and fishes from exposure to low potency agonists of the aryl hydrocarbon receptor: A cross-species quantitative adverse outcome pathway approach. Environ. Toxicol. Chem. 39(10): 2055-2064

J.A. Doering, S.C. Beitel, S. Patterson, B.K. Eisner, J.P. Giesy, M. Hecker, S. Wiseman. 2020. Aryl hydrocarbon receptor nuclear translocators (ARNT1, ARNT2, and ARNT3) of white sturgeon (Acipenser transmontanus): Sequences, tissue-specific expressions, and response to β-naphthoflavone. Comp. Biochem. Physiol. C. Toxicol.  Pharmacol. 231: 108726

G. Morandi, S. Wiseman, C. Sun, J.W. Martin, J.P. Giesy. 2020. Effects of chemical fractions from an oil sands end-pit lake on reproduction of fathead minnows. Chemosphere. 249:126073 

C. Hamilton, S. Wiseman, J. Copeland, M. Bomhof. 2020. Influence of post-exercise fasting on hunger and satiety in adults. Appl. Physiol. Nutr. Metab. DOI: 10.1139/apnm-2019-0947


Alharbi H, Morandi GD, Jones PD, Wiseman SB, Giesy JP. (2019). Comparison of the Effects of Extraction Techniques on Mass Spectrometry Profiles of Dissolved Organic Compounds in Oil Sands Process-Affected Water. Energy and Fuels. 33(8), 7001-7008.


Doering JS, Wiseman S, Giesy JP, Hecker M. (2018). A Cross-Species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life-Stage Mortality in Birds and Fishes. Environmental Science and Technology 52(13): 7524-7533. 

Tse TJ,  Doig LE,  Tang S,  Zhang Z,  Sun W, Wiseman SB,  Feng CX,  Liu H,  Giesy JP,  Hecker M, Jones PD. (2018). Combining High-Throughput Sequencing of sedaDNA and Traditional Paleolimnological Techniques to Infer Historical Trends in Cyanobacterial Communities. Environmental Science and Technology 52(12): 6842-6853. 

Redman AD, Parkerton TF,  Butler JD, Letinski DJ, Frank RA, Hewitt LM, Bartlett AJ, Gillis PL, Marentette JR, Parrott JL, Hughes SA, Guest R, Bekele A, Zhang K, Morandi G, Wiseman S, Giesy JP. (2018). Application of the Target Lipid Model and Passive Samplers to Characterize the Toxicity of Bioavailable Organics in Oil Sands Process-Affected Water. Environmental Science and Technology 52(14): 8039-8049. 

Morandi G, Wiseman SB, Guan M, Zhang XW, Martin JW, Giesy JP. (2017). Elucidating mechanisms of toxic action of dissolved organic chemicals in oil sands process-affected water (OSPW). Chemosphere. 186: 893-900.


Sun J, Peng H, Alharbi HA, Jones PD, Giesy JP, Wiseman SB. Identification of chemicals in oil sands process-affected water that cause oxidative stress. Environmental Science and Technology. 51(15): 8773–8781

Patterson S, Zee J, Wiseman S, Hecker M. (2017). Effects of chronic eposure to dietary selenomethionineon the physiological stress response in juvenile white sturgeon (Acipenser

transmontanus). Aquatic Toxicology. 186: 77-86. 

Peng H, Sun J, Saunders DMV, Codling G, Wiseman S, Jones PD, Giesy JP. (2017). Hydroylated 2-

Ethylheyl Tetrabromobenzoate Isomers in House Dust and Their Agonistic Potencies with Several Nuclear Receptors. Environmental Pollution. 227: 578-586.


Koglin S, Kammann U, Eichbaum K, Reininghaus M, Eisner B, Wiseman S, Hecker M, Buchinger

S, Reifferscheid G, Hollert H, Brinkmann M. (2016). Towards understanding the impacts of sediment

contamination on a native fish species - Transcriptional effects, EROD activity and biliary PAH

metabolites. Environmental Sciences Europe. 28(1): 28.

Brinkmann M, Koglin S, Eisner B, Wiseman S, Hecker M, Eichbaum K, Thalmann B, Buchinger S, Reifferscheid G, Hollert H. (2016). Characterisation of transcriptional responses to dioins and dioin-like contaminants in roach (Rutilus rutilus) using whole transcriptome analysis.. The Science of the Total Environment. 541: 412-423. 

Doering JA, Tang S, Peng H, Eisner BK, Sun J, Giesy JP, Wiseman S, Hecker M. (2016). High conservation in transcriptomic and proteomic response of white sturgeon to equipotent concentrations of

2,3,7,8-TCDD, PCB 77, and benzo[a]pyrene. Environmental Science and Technology. 50(9): 4826-4835.

Alharbi HA, Saunders D, Al-Mousa A, Alcorn J, Pereira AS, Martin JW, Giesy JP, Wiseman SB. (2016). Inhibition of ABC transport proteins by oil sands process affected water. Aquatic Toxicology. 170: 81-88.

Alharbi HA, Morandi G, Giesy JP, Wiseman SB. (2016). Effect of oil sands process-affected water on toxicity of retene to early life-stages of Japanese medaka (Oryzias latipes). Aquatic Toxicology. 176: 1-9.

Alharbi HA, Alcorn J, Al-Mousa A, Giesy JP, Wiseman SB. (2016). Toicokinetics and toicodynamics of chlorpyrifos is altered in embryos of Japanese medaka exposed to oil sands process-affected water: evidence for inhibition of P-glycoprotein. Journal of Applied Toxicology. 37: 591-601.

Tang S, Doering JA, Sun J, Beitel SC, Sheikh K, Patterson S, Crawford S, Giese JP, Wiseman SB, Hecker M. (2016). Linking oxidative stress and magnitude of compensatory responses with life-stage specific differences in sensitivity of white sturgeon (Acipenser transmontanus) to copper or cadmium. Environmental Science and Technology. 50(17): 9717-9726.

Sun J, Tang S, Peng H, Saunders D, Doering JA, Hecker M, Jones PD, Giesy JP, Wiseman SB. (2016). A combined transcriptomic and proteomic approach to identify toxicity pathways in early-life stages of Japanese medaka (Oryzias latipes) exposed to 1,2,5,6-tetrabromocyclooctane (TBCO). Environmental Science and Technology. 50(14): 7781–7790

Peng H, Chen CL, Cantin J, Saunders DMV, Sun J, Tang S, Codling G, Hecker M, Wiseman S, Jones PD, Li A, Rockne KJ, Sturchio NC, Cai, MH, Giesy JP. (2016). Untargeted screening and distribution of organo-iodine compounds in sediments from lake Michigan and the Arctic ocean. Environmental Science and Technology. 50(18): 10097–10105. 

Morandi G, Zhang K, Wiseman S, Pereira A, Martin JW, Giesy JP. (2016). Effect of lipid partitioning on predictions of acute toxicity of oil sands process affected water to embryos of fathead minnow (Pimephales promelas). Environmental Science and Technology. 50(16): 8858-8866.

Peng H, Chen C, Cantin J, Saunders DM, Sun J, Tang S, Codling G, Hecker M, Wiseman S, Jones PD, Li A, Rockne KJ, Sturchio NC, Giesy JP. (2016). Untargeted screening and distribution of organobromine compounds in sediments of lake Michigan. Environmental Science and Technology. 50(1): 321-330. 

Peng H, Sun J, Alharbi HA, Jones PD, Giesy JP, Wiseman SB. (2016). Peroxisome proliferator activated receptor γ is a sensitive target for oil sands process-affected water: effects on adipogenesis and

identification of ligands. Environmental Science and Technology. 50(14): 7816-7824. 

Zhang K, Wiseman S, Giesy JP, Martin JW. (2016). Bioconcentration of dissolved organic compounds from oil sands process-affected water by medaka (Oryzias latipes): importance of partitioning to phospholipids. Environmental Science and Technology. 50(12): 6574-6582.

Eisner BK, Doering JA, Beitel SC, Wiseman S, Raine JC, Hecker M. (2016). Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro. Environmental Toxicology and Chemistry. 35(1): 173-81.

Lari E, Wiseman S, Mohaddes E, Morandi G, Alharbi H, Pyle GG. (2016). Determining the effect of oil sands process-affected water on grazing behaviour of Daphnia magna, long-term consequences, and mechanism. Chemosphere. 146: 362-370. 


Morandi GD, Wiseman SB, Pereira A, Mankidy R, Gault IG, Martin JW, Giesy JP. (2015). Effects directed analysis of dissolved organic compounds in oil sands process-affected water. Environmental Science and Technology. 49(20): 12395-12404.

Leclair LA, Pohler L, Wiseman SB, He Y, Arens CJ, Giesy JP, Scully S, Wagner BD, van den Heuvel MR, Hogan NS. (2015). In vitro assessment of endocrine disrupting potential of naphthenic acidfractions derived from oil sands-influenced water. Environmental Science and Technology. 49(9): 5743-5752.

Al Naggar Y, Wiseman S, Sun J, Cutler GC, Aboul-Soud M, Naiem E, Mona M, Seif A, Giesy JP. (2015). Effects of environmentally-relevant mixtures of four common organophosphorus insecticides on the honey bee (Apis mellifera L.). Journal of Insect Physiology. 82: 85-91.

Peng H, Saunders DM, Sun J, Codling G, Wiseman S, Jones PD, Giesy JP. (2015). Detection, identification, and quantification of hydroxylated bis(2-ethylheyl)-tetrabromophthalate isomers in house dust. Environmental Science and Technology. 49(5): 2999-3006. 

Peng H, Chen C, Saunders DM, Sun J, Tang S, Codling G, Hecker M, Wiseman S, Jones PD, Li A, Rockne KJ, Giesy JP. (2015). Untargeted identification of organo-bromine compounds in lake

sediments by ultrahigh-resolution mass spectrometry with the data-independent precursor isolation and

characteristic fragment method. Analytical Chemistry. 87(20): 10237-10246. 

Redelstein R, Zielke H, Spira D, Feiler U, Erdinger L, Zimmer H, Wiseman S, Hecker M, Giesy JP, Seiler TB, Hollert H. (2015). Bioaccumulation and molecular effects of sediment-bound metals in zebrafish embryos. Environmental Science and Pollution Research International. 22(21): 16290-16304.

Saunders D, Podaima M, Codling G, Giesy JP, Wiseman S. (2015). A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka. Aquatic Toxicology. 158: 14-21.

Doering JA, Beitel SC, Eisner BK, Heide T, Hollert H, Giesy JP, Hecker M, Wiseman SB. (2015). Identification and response to metals of metallothionein in two ancient fishes: white sturgeon (Acipenser transmontanus) and lake sturgeon (Acipenser fulvescens). Comparative Biochemistry and Physiology. Toxicology and Pharmacology : 171: 41-48. 

Tompsett AR, Higley E, Pryce S, Giesy JP, Hecker M, Wiseman S. (2015). Transcriptional changes in African clawed frogs (enopus laevis) exposed to 17α-ethynylestradiol during early development. EcoToxicology. 24(2): 321-329. 

Saunders D, Podaima M, Wiseman S, Giesy JP. (2015). Effects of the brominated flame retardant TBCO on fecundity and profiles of transcripts of the HPGL-axis in Japanese medaka. Aquatic Toxicology. 160: 180-167

Doering JA, Farmahin R, Wiseman S, Beitel SC, Kennedy SW, Giesy JP, Hecker M. (2015). Differences in activation of aryl hydrocarbon receptors of white sturgeon relative to lake sturgeon are

predicted by identities of key amino acids in the ligand binding domain. Environmental Science and

Technology. 49(7): 4681-4689. 


Garcia-Reyero N, Kennedy AJ, Escalon BL, Habib T, Laird JG, Rawat A, Wiseman S, Hecker M, Denslow N, Steevens JA, Perkins EJ. (2014). Differential effects and potential adverse outcomes of ionic

silver and silver nanoparticles in vivo and in vitro. Environmental Science and Technology. 48(8): 4546-4555. 

Doering JA, Farmahin R, Wiseman S, Kennedy SW, Giesy JP, Hecker M. (2014). Functionality of arylhydrocarbon receptors (AhR1 and AhR2) of white sturgeon (Acipenser transmontanus) and implications for the risk assessment of dioxin-like compounds. Environmental Science and Technology. 48(14): 8219-8226. 

Doering JA, Wiseman S, Beitel SC, Giesy JP, Hecker M. (2014). Identification and expression of aryl hydrocarbon receptors (AhR1 and AhR2) provide insight in an evolutionary context regarding sensitivity

of white sturgeon (Acipenser transmontanus) to dioxin-like compounds. Aquatic Toxicology. 150: 27-35.


Wiseman SB, He Y, Gamal-El Din M, Martin JW, Jones PD, Hecker M, Giesy JP. (2013). Transcriptional responses of male fathead minnows exposed to oil sands process-affected water.

Comparative Biochemistry and Physiology. Toxicology and Pharmacology. 157(2): 227-235.

Tompsett AR, Wiseman S, Higley E, Giesy JP, Hecker M. (2013). Effects of exposure to 17α-ethynylestradiol during sexual differentiation on the transcriptome of the African clawed frog (Xenopus

laevis). Environmental Science and Technology. 47(9): 4822-4828.

Wiseman SB, Anderson JC, Liber K, Giesy JP. (2013). Endocrine disruption and oxidative stress in larvae of Chironomus dilutus following short-term exposure to fresh or aged oil sands process-affected water. Aquatic Toxicology. 142-143: 414-421. 

Thomas JK, Wiseman S, Giesy JP, Janz DM. (2013). Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Aquatic Toxicology. 130-131: 112-122.

Tompsett AR, Wiseman S, Higley E, Giesy JP, Hecker M. (2013). Effects of eposure to 17α-ethynylestradiol during larval development on growth, sexual differentiation, and abundances of transcripts in the liver of the wood frog (Lithobates sylvaticus). Aquatic Toxicology. 126: 42-51. 

Mankidy R, Wiseman S, Ma H, Giesy JP. (2013). Biological impact of phthalates. Toxicology Letters. 217(1): 50-58. 

Higley E, Tompsett AR, Giesy JP, Hecker M, Wiseman S. (2013). Effects of triphenyltin on growth and development of the wood frog (Lithobates sylvaticus). Aquatic Toxicology. 144-145: 155-161. 

Doering JA, Giesy JP, Wiseman S, Hecker M. (2013). Predicting the sensitivity of fishes to dioxin-like compounds: possible role of the aryl hydrocarbon receptor (AhR) ligand binding domain. Environmental Science and Pollution Research International. 20(3): 1219-1224. 

Brinkmann M, Hudjetz S, Kammann U, Hennig M, Kuckelkorn J, Chinoraks M, Cofalla C, Wiseman S, Giesy JP, Schäffer A, Hecker M, Wölz J, Schüttrumpf H, Hollert H. (2013). How flood events affect

rainbow trout: evidence of a biomarker cascade in rainbow trout after exposure to PAH contaminated

sediment suspensions. Aquatic Toxicology. 128-129: 13-24. 


Naile JE, Wiseman S, Bachtold K, Jones PD, Giesy JP. (2012). Transcriptional effects of perfluorinated compounds in rat hepatoma cells. Chemosphere. 86(3): 270-277.

He Y, Patterson S, Wang N, Hecker M, Martin JW, El-Din MG, Giesy JP, Wiseman SB. (2012). Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas). Water Research. 46(19): 6359-6368.

Liu F, Wiseman S, Wan Y, Doering JA, Hecker M, Lam MH, Giesy JP. (2012). Multi-species comparison of the mechanism of biotransformation of MeO-BDEs to OH-BDEs in fish. Aquatic Toxicology. 114-115: 182-188

He Y, Wiseman SB, Wang N, Perez-Estrada LA, El-Din MG, Martin JW, Giesy JP. (2012). Transcriptional responses of the brain-gonad-liver axis of fathead minnows exposed to untreated and

ozone-treated oil sands process-affected water. Environmental Science and Technology. 46(17): 9701-8.

Anderson JC, Wiseman SB, Wang N, Moustafa A, Perez-Estrada L, Gamal El-Din M, Martin JW, Liber K, Giesy JP. (2012). Effectiveness of ozonation treatment in eliminating toxicity of oil sands process affected water to Chironomus dilutus. Environmental Science and Technology. 46(1): 486-93.

Zhang K, Wan Y, Jones PD, Wiseman S, Giesy JP, Hu J. (2012). Occurrences and fates of hydroxylated polybrominated diphenyl ethers in marine sediments in relation to trophodynamics.

Environmental Science and Technology. 46(4): 2148-55.

Bursian SJ, Moore J, Newsted JL, Link JE, Fitzgerald SD, Bello N, Bhat VS, Kay D, Zhang , Wiseman S, Budinsky RA, Giesy JP, Zwiernik MJ. (2012). Incidence of jaw lesions and activity

and gene epression of hepatic P4501A enzymes in mink (Mustela vison) eposed to dietary 2,3,7,8-

tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

Environmental Toxicology and Chemistry. 31(11): 2545-56.

Tompsett AR, Wiseman S, Higley E, Pryce S, Chang H, Giesy JP, Hecker M. (2012). Effects of 17α-ethynylestradiol on sexual differentiation and development of the African clawed frog (Xenopus laevis).Comparative Biochemistry and Physiology. Toxicology and Pharmacology : CBP. 156(3-4): 202-210.

Anderson J, Wiseman SB, Moustafa A, El-Din MG, Liber K, Giesy JP. (2012). Effects of exposure to oil sands process-affected water from experimental reclamation ponds on Chironomus dilutus. Water Research. 46(6): 1662-1672. 

Doering JA, Wiseman S, Beitel SC, Tendler BJ, Giesy JP, Hecker M. (2012). Tissue specificity of aryl hydrocarbon receptor (AhR) mediated responses and relative sensitivity of white sturgeon (Acipenser transmontanus) to an AhR agonist. Aquatic Toxicology. 114-115: 125-133.


Wiseman S, Thomas JK, McPhee L, Hursky O, Raine JC, Pietrock M, Giesy JP, Hecker M, Janz

DM. (2011). Attenuation of the cortisol response to stress in female rainbow trout chronically exposed to

dietary selenomethionine. Aquatic Toxicology. 105(3-4): 643-651. 

Cohen-Barnhouse AM, Zwiernik MJ, Link JE, Fitzgerald SD, Kennedy SW, Hervé JC, Giesy JP, Wiseman S, Yang Y, Jones PD, Wan Y, Collins B, Newsted JL, Kay D, Bursian SJ. (2011). Sensitivity of Japanese quail (Coturni japonica), Common pheasant (Phasianus colchicus), and White Leghorn chicken (Gallus gallus domesticus) embryos to in ovo eposure to TCDD, PeCDF, and TCDF.

Toxicological Sciences. 119(1): 93-103. 

Wiseman S, Vijayan MM. (2011). Aroclor 1254 disrupts liver glycogen metabolism and enhances acute stressor-mediated glycogenolysis in rainbow trout. Comparative Biochemistry and Physiology. Toxicology and Pharmacology. 154(3): 254-260. 

Wiseman SB, Wan Y, Chang H, Zhang, Hecker M, Jones PD, Giesy JP. (2011). Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: environmental sources, metabolic relationships, and relative toxicities. Marine Pollution Bulletin. 63(5-12): 179-188.

Zhang , Wiseman S, Yu H, Liu H, Giesy JP, Hecker M. (2011). Assessing the toicity of naphthenic

acids using a microbial genome wide live cell reporter array system. Environmental Science and Technology. 45(5): 1984-1991. 

Zhang , Chang H, Wiseman S, He Y, Higley E, Jones P, Wong CK, Al-Khedhairy A, Giesy JP, Hecker M. (2011). Bisphenol A disrupts steroidogenesis in human H295R cells. Toxicological Sciences. 121(2): 320-327.

Pourrezaei P, Drzewicz P, Wang Y, Gamal El-Din M, Perez-Estrada LA, Martin JW, Anderson J, Wiseman S, Liber K, Giesy JP. (2011). The impact of metallic coagulants on the removal of organic

compounds from oil sands process-affected water. Environmental Science and Technology. 45(19): 8452-8459. 

Bradley PW, Wan Y, Jones PD, Wiseman S, Chang H, Lam MH, Long DT, Giesy JP. (2011). PBDEs and methoxylated analogues in sediment cores from two Michigan, USA, inland lakes. Environmental Toxicology and Chemistry. 30(6): 1236-1242. 

Cohen-Barnhouse AM, Zwiernik MJ, Link JE, Fitzgerald SD, Kennedy SW, Giesy JP, Wiseman S, Jones PD, Newsted JL, Kay D, Bursian SJ. (2011). Developmental and posthatch effects of in ovo exposure to 2,3,7,8-TCDD, 2,3,4,7,8-PECDF, and 2,3,7,8-TCDF in Japanese quail (Coturni japonica), common pheasant (Phasianus colchicus), and white leghorn chicken (Gallus gallus domesticus) embryos.

Environmental Toxicology and Chemistry. 30(7): 1659-1668. 

He Y, Wiseman SB, Hecker M, Zhang , Wang N, Perez LA, Jones PD, El-Din MG, Martin JW, Giesy JP. (2011). Effect of ozonation on the estrogenicity and androgenicity of oil sands process-affected water. Environmental Science and Technology. 45(15): 6268-6274. 

Wiseman S, Thomas JK, Higley E, Hursky O, Pietrock M, Raine JC, Giesy JP, Janz DM, Hecker M. (2011). Chronic exposure to dietary selenomethionine increases gonadal steroidogenesis in female rainbow trout. Aquatic Toxicology. 105(3-4): 218-226. 

Wiseman S, Jorgensen EH, Maule AG, Vijayan MM. (2011). Contaminant loading in remote Arctic lakes affects cellular stress-related proteins expression in feral charr. Polar Biology. 63(6): 179-188. 



The lab is equipped with basic and specialized equipment needed for ecotoxicology studies.  Equipment for gene expression analysis (qPCR and Western Blotting), biochemical assays (specialized plate readers), fish behaviour (Daniovision/ Danioscope/ Ethovision), and embryo manipulation (microinjection) are available.  In addition, the Aquatic Research Facility is equipped to hold any small bodies fish, and can support studies with all life stages, from embryos to adults.



Rm 1058, Alberta Water and Environmental Sciences Building, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada